Kollidon CLF

The insoluble grades of Kollidon® are widely used in the pharmaceuticals industry
because of their swelling properties. They are thus predominantly used as disintegrants
in solid oral dosage forms such as tablets. Furthermore their application as
pharmaceutical excipients is triggered by their ability to hydrophilize insoluble
drugs, to stabilize suspensions and to form complexes.The products differ not only in their particle size distributions but in other physical properties, too, such as in their bulk density and their swelling behavior.The product differentiation is done mainly by the particle size distribution. The products differ not only in their particle size distributions but in other physical properties, too, such as in their bulk density and their swelling behavior. Kollidon CL F has a swelling pressure of approx 30 kpa, hydration capacity of 5.0-6.6 g water/g polymer along with a particle size 50-100 µm.It has a bulk density of 0.18 – 0.28 g/ml. Like the soluble grades of Kollidon®, the insoluble Kollidon® CL-grades form chemical
complexes or associates with a large number of drugs and other substances. The
formation of the complexes is reversible and no complex formation occurs in alkaline
medium. The usual quantity of Kollidon® CL, Kollidon® CL-F and Kollidon® CL-SF used is a
range of 2 – 8%, as a proportion of the tablet weight. Kollidon CL F has a strong disintegration power in combination with a smooth surface and is suitable for wet granulation process.