Kolliphor HS 15

Kolliphor® HS 15 is a potent non-ionic solubilizer and emulsifying agent, with low toxicity. Ideal for solubilizing low-solubility actives in microemulsions, it helps tackle even the toughest solubilization challenges. It is used for manufacturing aqueous parenteral preparations with vitamins A, D, E and K, plus lipophilic APIs such as propanidid, miconazole, alfadolone, alfaxalone, nifedipine, and piroxicam. Kolliphor® HS 15 is soluble in water, ethanol, and 2-propanol. As a solubilizer, it is particularly suitable for parenteral and oral dosage forms, and lends itself well to veterinary formulations.

Former tradename: Solutol® HS 15
Generic name: Macrogol 15 Hydroxystearate, Polyoxyl 15 Hydroxystearate
CAS-No: 70142-34-6
Regulatory Status: Kolliphor® HS 15 conforms to the requirements of the European Pharmacopoeia monograph “Macrogol-15-Hydroxystearat”.
Applications: The main application is as nonionic solubiliser for manufacturing of aqueous parenteral preparations.
Description: Kolliphor® HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30 °C.
Composition: Kolliphor® HS 15 consists of polyglycol mono- and di-esters of 12-hydroxystearic acid (= lipophilic part) and of about 30% of free polyethylene glycol (= hydrophilic part).The free polyethylene glycol can be determined by HPLC. The method is available on request.
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