Kolliphor® HS 15 is a potent non-ionic solubilizer and emulsifying agent, with low toxicity. Ideal for solubilizing low-solubility actives in microemulsions, it helps tackle even the toughest solubilization challenges. It is used for manufacturing aqueous parenteral preparations with vitamins A, D, E and K, plus lipophilic APIs such as propanidid, miconazole, alfadolone, alfaxalone, nifedipine, and piroxicam. Kolliphor® HS 15 is soluble in water, ethanol, and 2-propanol. As a solubilizer, it is particularly suitable for parenteral and oral dosage forms, and lends itself well to veterinary formulations.
| Former tradename: | Solutol® HS 15 |
| Generic name: | Macrogol 15 Hydroxystearate, Polyoxyl 15 Hydroxystearate |
| CAS-No: | 70142-34-6 |
| Regulatory Status: | Kolliphor® HS 15 conforms to the requirements of the European Pharmacopoeia monograph “Macrogol-15-Hydroxystearat”. |
| Applications: | The main application is as nonionic solubiliser for manufacturing of aqueous parenteral preparations. |
| Description: | Kolliphor® HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30 °C. |
| Composition: | Kolliphor® HS 15 consists of polyglycol mono- and di-esters of 12-hydroxystearic acid (= lipophilic part) and of about 30% of free polyethylene glycol (= hydrophilic part).The free polyethylene glycol can be determined by HPLC. The method is available on request. |
