Kolliphor P 407 Micrco

In recent years an increasing number of poorly soluble substances have been developed. This requires the addition of solubilizers in order to make those substances bioavailable. As solid oral dosage forms are the preferred formulation, solubilizers are required with special galenical properties.Poloxamers such as Kolliphor® P are compounds with a long history of use in the field of solubilization that have excellent properties. Kolliphor® P micro grades are micronized poloxamers working as solubilization agents. A special micronization process is applied to achieve superior properties. Kolliphor® P micro grades can be used in several pharmaceutical application fields:dissolution enhancer for actives in tablets and capsules, lubricant for actives incompatible with magnesium stearate, i.e. ibuprofen, polishing agent for film-coated tablets, dispersing / wetting agent and water soluble lubricants, i.e. for effervescent tablets. Due to the low average particle size that is in the same range as for active ingredients a direct blending with the active is possible with a low tendency of demixing. This allows a very cost- and time-saving production.In solid dosage forms the micoprilled product Kolliphor® P 407 micro has been successfully formulated. It is soluble in water, alcohol and other solvents.

Chemical name: Micronized Poloxamer
Former trade name: Lutrol® micro 127
CAS-No: 06-11-03
INCI: Poloxamer 407
HSN Code 34021300
Compendial Name: Ph. Eur., USP / NF: Poloxamer 407. Kolliphor ® P 407 micro products are also JPE certified (Japanese Pharmaceutical Excipients): Polyoxyethylene (196) Polyoxylpropylene (67) glycol


Need Help?

Contact us for further information about Transchem Corporation..