Derived from hydrogenated castor oil and ethylene oxide, Kolliphor® RH40 is used as a non-ionic oil-in-water solubilizer and emulsifying agent. It is particularly suitable for fat-soluble vitamins and demonstrates exceptional chemical stability. This tried-and-trusted solubilizer scored highest on resistance to enzymatic digestion in a study of various surfactants, highlighting its potential to enhance patient safety. Kolliphor® RH40 is widely used in self-emulsifying drug delivery systems (SEDDS) or microemulsifying systems (SMDDS) in combination with a co-solubilizer and/or co-solvent. What’s more, Kolliphor® RH40 is almost tasteless – making it ideal for oral applications.
| Chemical name: | Polyoxyl castor oil |
| Generic name: | Polyoxyl 40 Hydrogenated Castor Oil (USP, current edition), Macrogolglycerol Hydroxystearate (Ph. Eur., current edition). |
| Former Tradename: | Cremophor® RH 40 |
| CAS-No: | 61788-85-0 |
| INCI: | PEG-40 Hydrogenated Castor Oil |
| Regulatory Status: | Kolliphor® RH 40 meets the requirements of the current Ph.Eur. monograph “Macrogolglycerol hydroxystearate”. It also conforms to the latest edition of the USP/NF monograph “Polyoxyl 40 Hydrogenated Castor Oil”. |
| Applications: | The main application is as solubiliser and emulsifier in oral and topical liquid and semi-solid dosage forms. |
| Chemical nature: | Kolliphor® RH 40 is a nonionic solubilizer and emulsifying agent obtained by reacting 1 mole of hydrogenated castor oil with 40 moles of ethylene oxide. The main constituent of Kolliphor® RH 40 is glycerol polyethylene glycol hydroxy- stearate, which, together with fatty acid glycerol polyglycol esters, forms the hydrophobic part of the product. The hydrophilic part consists of polyethylene glycols and glycerol ethoxylate. |
