Kollisolv PEG 300

The low-molecular weight liquid polyethylene glycols Kollisolv® PEG 300 and Kollisolv® PEG 400 are excellent solvents for a large number of substances that do not readily dissolve in water. They are therefore widely used as solvents and solubilising agents for active substances and excipients in liquid and semi-solid preparations. It is the ability of PEGs to form complexes with active substances that is responsible for their excellent solvent power. However, equilibrium constants for complex formation vary considerably from one substance to another, and certain drugs such as Penicillin G and Bacitracin can even become inactivated. The effect of the polyethylene glycol on the efficacy and absorption of a drug must therefore always be determined in tests. With regard to incompatible substances, please see the remarks in the European Pharmacopoeia, Vol. II/3, Monographs M1, Macrogol 300, p. 3. Polyethylene glycols can also be used to adjust the viscosity of liquid pharmaceutical preparations and ointments, to modify their absorption properties and to stabilise the preparation.

Chemical name: Polyethylene glycol
Trivial names: Polyethylene glycol, macrogol, polyglycol, polyoxyethylene and polydiol
Former tradename: Lutrol® E 300
CAS-No: 25322-68-3
Regulatory Status: Macrogol in Ph. Eur. and Polyethyleneglycol in USP/NF
Applications: The main application is as solvent for oral, topical and parenteral preparations.
Description: Kollisolv® PEG 300 and Kollisolv® PEG 400 are colourless, almost odourless and tasteless liquids at room temperature. The products are manufactured by alkali-catalysed polymerisation of ethylene oxide with subsequent neutralisation of the catalyst.
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