Kollisolv PYR

Kollisolv® PYR is approved for the use in veterinary medicines. The product is mainly used as a solvent for intravenous applications or topical preparations. It has also been suggested for use in human pharmaceutical formulations as solvent in parenteral, oral, and topical applications. In topical applications, Kollisolv® PYR appears to be effective penetration enhancer. Pyrrolidone has also been investigated for their application in controlled-release depot formulations.Kollisolv® PYR is a colorless or slightly colored liquid, which solidifies at room temperature and has a characteristic odor. It is soluble in water and a number of organic solvents, i.e. ethanol, isopropyl alcohol and aromatic hydrocarbons. Solutions of Kollisolv® PYR in water of up to 50% have a viscosity of no more than 4 m Pa. Kollisolv® PYR shows strong antimicrobial effectiveness against gram-positive and gram-negative bacteria and moulds. This results in additional preservation of the application formulation possibly no longer being necessary.